- Orbis begins using Gefion, Denmark’s first AI supercomputer
- Composed of 1,528 NVIDIA H100 Tensor Core GPUs, system is optimized for large-scale, AI-driven projects
- Enables significant expansion of macrocycle chemical space exploration by Orbis’ nGen platform
- New AI/ML capacity will leverage large proprietary datasets and generative AI to design novel orally available macrocycle alternatives to existing biologics
COPENHAGEN – June 6, 2025 – Orbis Medicines, a leader in oral macrocycle drug discovery, and the Danish Center for AI Innovation (DCAI) today announced that Orbis has begun using Denmark’s first AI supercomputer, Gefion, which is owned and operated by DCAI. Gefion will allow the company to accelerate its mission of developing oral alternatives to widely used biologics and targeting important intra- and extracellular proteins that are currently difficult or impossible to drug with orally bioavailable compounds.
Orbis is pioneering the systematic discovery and development of targeted, orally available macrocycles for diseases and targets traditionally treated with biologics. The company develops compounds known as nCycles, which can address a wide range of validated protein targets with unique oral bioavailability and membrane permeability features.
Our advanced nGen platform helps us quickly create large numbers of custom-designed macrocycles with unique properties and broad medical applicability. By combining this platform with Gefion’s computing power, we can extend beyond the nearly 140 billion compounds in our existing libraries to design entirely new collections of these molecules. This means we can explore an even broader range of chemical possibilities and more fully unlock the potential of macrocycles to improve healthcare.
Morten Graugaard
Orbis CEO
Orbis’ nGen platform, which has already been used to design, synthesize and test more than 700,000 individual nCycles, is an ideal application for Gefion’s capabilities. Combining the power of this supercomputer with our in-house target nCycle data collection, generative AI, and nCycle synthesis capabilities will accelerate the development of orally available macrocycles that have the potential to disrupt the current biologics market and provide new treatment options for patients.
Mikael Dolsten, M.D., Ph.D.
Orbis Medicines Board Chair
Gefion is designed to deliver AI innovation at scale through immense computing power applied to the most challenging problems. As a biomedical start-up with its own internal AI technology applied to drug design and the ability to generate vast data sets, Orbis is an ideal partner to demonstrate what Gefion can unlock when matched with specialist expertise.
Dr. Nadia Carlsten
CEO of DCAI
DCAI’s Gefion supercomputer contains 1,528 NVIDIA GPUs and is optimized for large-scale AI-driven projects. Gefion enables innovators to utilize advanced computation to accelerate discovery in various fields, including biotechnology and drug discovery. Gefion has previously been used by researchers, start-ups, and large enterprises to develop new AI models and perform simulations in weather modeling, quantum computing, and business automation.
Media:
Matt Crenson
Ten Bridge Communications
+1 (917) 640-7930
mcrenson@tenbridgecommunications.com
General enquiries for DCAI & Gefion
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