Complement Therapeutics Enrols First Patient in Non- interventional i-GAIN Study of People Diagnosed with Geographic Atrophy

London England – 09 February 2023 – Complement Therapeutics Ltd (CTx), a preclinical stage biotechnology company, today announced enrolment of the first patient in a natural history study of people who have been diagnosed with geographic atrophy (GA), secondary to age-related macular degeneration (AMD); also called late dry AMD, GA is a disease which causes irreversible blindness and currently has no approved treatments.

The i-GAIN (investigating Geographic Atrophy Insights) study is a one-year natural history study in patients who have a confirmed diagnosis of GA in one or both eyes. The study is designed to evaluate the relationship between genetics, blood biomarkers and phenotypic changes in the eye of people with GA. Data from the i-GAIN study will support the clinical development of CTx001, CTx’s lead gene therapy asset for the treatment of GA, particularly enabling the identification and stratification of patients with complement-driven AMD for future interventional studies.

Dr Marta Ugarte, consultant ophthalmologist and principal investigator of the i- GAIN study said “Today’s announcement is an important milestone in enabling researchers to gain a better understanding of this disease. We look forward to generating and analysing data from the i-GAIN study, which will provide insights into how the disease progresses.”

“A deeper understanding of the natural history of GA will provide important insights supporting the development of innovative medicines which can prevent vision loss in these patients,” said Dr Rafiq Hasan, Chief Executive Officer at Complement Therapeutics.